Non Spermicidal Condoms: Full List UK Condoms.uk Protection works best when you use it right. Follow these simple #Condom do's and don'ts to take care of yourself and your partners. Do spermicide condoms work? Pros and cons Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia, and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex.